Two sample MR report
C19orf33_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.3791439 | 0.8380692 | 0.7295325 |
| Weighted median | 3 | 0.0362912 | 0.0162312 | 0.0253587 |
| Inverse variance weighted | 3 | 0.0403388 | 0.0125679 | 0.0013288 |
| Simple mode | 3 | 0.0344111 | 0.0186865 | 0.2068931 |
| Weighted mode | 3 | 0.0332798 | 0.0186074 | 0.2155905 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.722000 | 1 | 0.1894358 |
| Inverse variance weighted | 2.153576 | 2 | 0.3406880 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.3080791 | 0.6153893 | 0.7045147 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.36e-05 | 0 | TRUE | 0.4917903 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
